Terrain Ten Highlight: Microbiome Health

In the health world, we recognize the profound influence of the microbiome on overall health and disease, including cancer. Within the framework of The Metabolic Approach to Cancer, the microbiome is seen as a critical terrain factor in both cancer prevention and integrative cancer care.

How does the microbiome influence cancer?

1. Immune System Regulation

Approximately 70% of the immune system resides in the gut. A diverse and balanced microbiome plays a key role in educating and regulating immune responses, including the ability to recognize and attack cancer cells.

2. Inflammation Modulation

Dysbiosis—an imbalance in the microbial ecosystem—can contribute to chronic, systemic inflammation, a well-known driver of cancer. Supporting a healthy microbiome helps modulate inflammatory responses.

3. Metabolism of Carcinogens

Gut microbes influence how the body processes environmental toxins and dietary components. Some bacteria can activate carcinogens, while others help neutralize and eliminate them, impacting overall cancer risk.

4. Response to Cancer Therapies

The composition of the gut microbiota can influence how individuals respond to treatments like chemotherapy and immunotherapy. A well-supported microbiome may enhance therapeutic efficacy and reduce adverse effects.

5. Nutrient Synthesis and Absorption

The microbiome assists in the breakdown and absorption of nutrients, including those that are critical for immune resilience and recovery during cancer treatment.

Supporting the Microbiome During Cancer and Beyond

We can take many steps to support and restore microbiome health—both for cancer prevention and as part of a holistic strategy during and after cancer treatment:

• Nourishing Your Body

  A diverse, plant-rich diet high in fiber and polyphenols feeds our beneficial bacteria. Even when using a therapeutic low-carbohydrate approach, we emphasize an abundance of colorful, phytonutrient-dense plants. This is the SuperKeto way!

  
  

• Probiotics and Prebiotics

  These can be helpful for restoring balance, though bioindividual considerations are essential. For instance, in cases of neutropenia (low white blood cell count), probiotic use may need to be avoided temporarily. See your Integrative Metabolic Oncology doctor to determine if they are right for you. Another way to bolster your gut health is through fermented foods like sauerkraut, kimchi, and homemade therapeutic yogurts.

  
  

• Mindful Antibiotic Use

  While antibiotics are sometimes necessary during cancer care (e.g., post-surgical), overuse or inappropriate prescribing can severely disrupt the microbiome. I often advise clients to avoid fluoroquinolones like ciprofloxacin (Cipro), which are particularly harmful to gut flora when alternatives are available.

  
  

• Lifestyle Practices

  Regular physical activity, restorative sleep, and stress-reducing practices (like meditation, time in nature, or breathwork) all contribute to a healthier microbiome.

The Bigger Picture

Cancer treatments can cause significant damage to the gut microbiota. While it may not always be possible to protect the microbiome during active treatment, we prioritize rebuilding and rebalancing afterward as part of a personalized, bioindividual recovery plan. Ultimately, maintaining a healthy microbiome is a foundational piece of cancer prevention and an essential pillar of integrative cancer support. In The Metabolic Approach to Cancer, the microbiome is not just one of the Terrain 10 to consider—it is necessary for healing and thriving!